Celery Seed Extract

Background 

Celery Seed Extract is derived from the seeds of Apium graveolens, a plant cultivated for centuries as both a culinary ingredient and traditional herbal remedy. The seeds contain a variety of naturally occurring bioactive compounds, including phthalides (particularly 3-n-butylphthalide), flavonoids, apigenin, luteolin, and volatile oils, which contribute to their antioxidant and wellness-supporting properties. 

Today, Celery Seed Extract is commonly used in dietary supplements to support cardiovascular health, healthy inflammatory responses, joint comfort, and overall wellness. It has also gained attention for its potential role in supporting healthy blood pressure already within the normal range. 

Traditional Uses 

Celery seed has been used for centuries in Ayurvedic medicine, Traditional Chinese Medicine, and European herbal traditions. Historically, it was valued for supporting healthy digestion, promoting urinary tract function, and maintaining joint comfort. Herbal practitioners also used celery seed to encourage healthy fluid balance and support overall vitality. 

 Today, Celery Seed Extract continues to be used to promote cardiovascular wellness, healthy circulation, antioxidant protection, and normal inflammatory balance. 

What Does Science Tell Us? 

Celery Seed Extract contains several bioactive compounds that support health through multiple mechanisms. One of the most studied is 3-n-butylphthalide (3nB), a naturally occurring compound that may help promote healthy blood vessel function by supporting normal vascular relaxation and circulation. 

Clinical research suggests Celery Seed Extract may help maintain healthy blood pressure already within the normal range. In a randomized, triple-blind, placebo-controlled clinical trial, adults with hypertension who supplemented with celery seed extract for four weeks experienced significant improvements in systolic and diastolic blood pressure compared with placebo, without significant adverse effects. While these findings are encouraging, larger clinical studies are needed to confirm the long-term benefits. 

Celery seed is also rich in flavonoids and other antioxidant compounds that help protect cells from oxidative stress. Laboratory research suggests these phytochemicals support healthy inflammatory responses and contribute to cardiovascular and metabolic wellness. 

In addition, traditional and emerging research suggests Celery Seed Extract supports healthy urinary function by promoting normal fluid balance. While this mild diuretic activity has been recognized for centuries, additional human research is needed to better understand its role in urinary and kidney health. 

Overall, current evidence supports Celery Seed Extract as a botanical that promotes cardiovascular health, antioxidant protection, healthy circulation, and overall wellness. 

Safety 

Celery Seed Extract is generally well tolerated when used as directed. Human clinical studies have reported a favorable safety profile, with few adverse effects observed at commonly studied doses. 

Because celery seed may help support healthy blood pressure and fluid balance, individuals taking blood pressure medications, diuretics, anticoagulants, or medications for diabetes should consult a healthcare professional before use. Individuals with known celery allergies should avoid celery seed products, as allergic reactions can occur. 

Pregnant or nursing women and individuals managing a medical condition should consult a qualified healthcare provider before beginning supplementation. 

References 

1. Hedayati N, et al. Effect of celery (Apium graveolens) seed extract on hypertension: A randomized, triple-blind, placebo-controlled, cross-over clinical trial. Phytotherapy Research. 2022. 
2. Hedayati N, et al. Safety evaluation and biochemical efficacy of celery seed extract (Apium graveolens) capsules in hypertensive patients: A randomized, triple-blind, placebo-controlled, cross-over clinical trial. Journal of Complementary and Integrative Medicine. 2022. 
3. Effects of celery (Apium graveolens) on blood pressure, glycemic and lipid profile in adults: A systematic review and meta-analysis of randomized controlled trials. Frontiers in Nutrition. 2025. 
4. Fazal SS, Singla RK. Review on the pharmacognostical and pharmacological characterization of Apium graveolens Linn. Indo Global Journal of Pharmaceutical Sciences. 2012.